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首页> 外文OA文献 >Differential expression of lymphocyte function-associated antigen (LFA-1) on peripheral blood leucocytes from individuals with Down's syndrome.
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Differential expression of lymphocyte function-associated antigen (LFA-1) on peripheral blood leucocytes from individuals with Down's syndrome.

机译：唐氏综合症患者外周血白细胞上淋巴细胞功能相关抗原（LFA-1）的差异表达。

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摘要

We analysed the expression of lymphocyte function-associated antigen LFA-1 on the cell surface of peripheral blood lymphocytes, monocytes and granulocytes from 20 children with Down's syndrome. No differences in LFA-1 expression was found within monocytes or granulocytes from either normal or Down's syndrome children; however, a clear-cut difference was observed on lymphoid cells. Both normal and Down's syndrome lymphocytes displayed a bimodal pattern of LFA-1 staining by flow cytometry, with a predominance of cells with low expression in normal population, and an increased proportion of lymphocytes with high level of LFA-1 expression in Down's syndrome children. This difference correlates well with the abnormal proportion of T cell subsets and inversion of CD4/CD8 observed in a majority of our cases, and therefore, it could merely reflect the increase of certain T cell subsets normally expressing higher number of LFA-1 molecules. Taken together, our results do not support an abnormally increased expression of leucocytes integrins in trisomy 21 cells, and raise some doubt about the suggested role of the abnormal cellular expression of LFA-1 in the pathogensis of secondary immunodeficiency associated to Down's syndrome.
机译：我们分析了20名唐氏综合症患儿外周血淋巴细胞，单核细胞和粒细胞的细胞表面淋巴细胞功能相关抗原LFA-1的表达。在正常或唐氏综合症患儿的单核细胞或粒细胞中，LFA-1表达没有差异。然而，在淋巴样细胞上观察到明显的差异。正常和唐氏综合症淋巴细胞均通过流式细胞术显示出双峰模式的LFA-1染色，在正常人群中占主导地位的是低表达细胞，唐氏综合症患儿中LFA-1表达水平较高的淋巴细胞比例增加。这种差异与我们大多数病例中观察到的T细胞亚群的异常比例和CD4 / CD8倒置密切相关，因此，它仅反映了通常表达更高数量LFA-1分子的某些T细胞亚群的增加。两者合计，我们的结果不支持三体性21细胞中白细胞整合素的表达异常增加，并且对LFA-1异常表达在唐氏综合症相关的继发性免疫缺陷病的发病机制中的作用提出了一些疑问。

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